Skip to Content

Can You Take Creatine With Multivitamins? (Is It Safe?)

Both creatine and multivitamins are safe supplements when taken in isolation, and there’s no current evidence to suggest that it’s harmful to take creatine and multivitamins together.

In this article, we look at the benefits of creatine and multivitamins and see if there are any further benefits of mixing these 2 compounds.

What Is Creatine?

Creatine is a natural organic acid that’s made in the body to help provide energy to cells, particularly muscle cells.

It’s naturally found in red meat and fish, and some people take creatine supplements to improve their performance.

Benefits of Creatine

Creatine Helps Increase Muscle Mass

A review of creatine supplementation concluded that creatine increases muscle hypertrophy (i.e. muscle growth) in all healthy young populations.

Some of the studies even showed that creatine increases muscle growth in untrained populations, suggesting that creatine was the direct cause of increased muscle mass.

Creatine Improves Athletic Performance

There are lots of studies which demonstrate creatine’s ability to improve physical performance.

In one of these studies, 8 ice-hockey players supplemented with creatine and 8 ice-hockey players took a placebo.

The results showed that those who took creatine had significantly more power in their sprinting.

Creatine Helps Prevent Fatigue

Another physical benefit of creatine is that it can help reduce muscular fatigue.

For example, in one study, 15 people took either a placebo or 20g of creatine per day for 5 days before performing a cycle test.

Interestingly, those who took creatine had delayed onset of fatigue during the test.

Creatine Improves Cognitive Function

One of the lesser-known benefits of creatine is its ability to improve mental function.

In a study of older people, creatine improved the subjects’ memory and recall ability.

What Are Multivitamins?

Multivitamins are supplements that contain various vitamins and minerals. They’re available in many forms, including tablets, capsules, liquids, and powders.

People typically take multivitamins to ensure they’re getting enough vitamins and minerals in their diet.

Benefits of Multivitamins

Multivitamins May Reduce Cancer Risk

There’s some research which suggests that multivitamins may reduce the risk of cancer.

For example, a meta-analysis of 5 randomized controlled trials found that men who took multivitamins had a 31% reduced risk of cancer.

Interestingly, there was no effect in women.

The evidence regarding cancer and multivitamin use is mixed and further research is required before making strong conclusions.

Multivitamins May Improve Heart Disease Outcomes

Many people take multivitamins to improve their heart health.

A recent study found that women, but not men, who took multivitamins for more than 3 years had a lower risk of dying of heart disease.

However some other studies suggest that there’s no correlation between risk of heart attack death and multivitamin intake, so more research is required.

Multivitamins May Improve Eye Health

Many multivitamins contain antioxidants, such as vitamin A.

There’s some evidence which suggests that antioxidants may help prevent age-related macular degeneration, which is one of the leading causes of blindness.

Are There Any Benefits of Taking Creatine And Multivitamins Together?

As there are currently no studies, it’s unclear whether taking creatine and multivitamins together provides further benefits than taking them individually.

When Is The Best Time To Take Creatine With Multivitamins?

Research shows that creatine is best taken after your workout for maximizing muscle and strength gains.

If you take these creatine and multivitamins supplements purely for muscle gain, then you should take them together after exercising for optimal results.


There’s no evidence to suggest that it’s harmful taking creatine and multivitamins together but there’s also no evidence to suggest that it’s beneficial.

That being said, both creatine and multivitamins can offer numerous benefits when taken individually.

That’s all for this article, but can you take creatine and citrulline together? Or what about creatine and collagen together?

Hope this helped!